Wheelie's style has been big for me ever since Optimus Rhyme. I'd try to recall his lyrics and match his pace. His songs hit a variet of topics. With Stenobot's synth tracks, production is manageable.
MC Frontalot's ability to create complex wording and rhythm on a variety of topics in such a detached manner make for some amazing songs that flow from start to end. See: Charity Case
Music can have some generic effects on the mind, like soothing or energizing, but these effects have been well-explored. The human psyche is a largely unexplored frontier, and synth is a travel method